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Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success

BACKGROUND: Multiple short hairpin RNA (shRNA) gene therapy strategies are currently being investigated for treating viral diseases such as HIV-1. It is important to use several different shRNAs to prevent the emergence of treatment-resistant strains. However, there is evidence that repeated express...

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Detalles Bibliográficos
Autores principales:	Mcintyre, Glen J, Yu, Yi-Hsin, Tran, Anna, Jaramillo, Angel B, Arndt, Allison J, Millington, Michelle L, Boyd, Maureen P, Elliott, Fiona A, Shen, Sylvie W, Murray, John M, Applegate, Tanya L
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775741/ https://www.ncbi.nlm.nih.gov/pubmed/19878571 http://dx.doi.org/10.1186/1743-422X-6-184

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