Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

BACKGROUND: Huntington's disease (HD) is an inherited neurogenerative disease caused by an abnormal expansion of glutamine repeats in the huntingtin protein. There is currently no treatment to prevent the neurodegeneration caused by this devastating disorder. Huntingtin has been shown to be a p...

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Detalles Bibliográficos
Autores principales: Pineda, Jose R, Pardo, Raúl, Zala, Diana, Yu, Hua, Humbert, Sandrine, Saudou, Frédéric
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776580/
https://www.ncbi.nlm.nih.gov/pubmed/19860865
http://dx.doi.org/10.1186/1756-6606-2-33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776580/
https://www.ncbi.nlm.nih.gov/pubmed/19860865
http://dx.doi.org/10.1186/1756-6606-2-33

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