Immune complex relay by subcapsular sinus macrophages and non-cognate B cells drives antibody affinity maturation

Subcapsular sinus (SCS) macrophages capture antigens from lymph and present them intact for B cell encounter and follicular delivery. However, the properties of SCS macrophages are poorly defined. Here we show SCS macrophage development depended on lymphotoxin-α1β2 and the cells had low lysosomal en...

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Detalles Bibliográficos
Autores principales: Phan, Tri Giang, Green, Jesse A., Gray, Elizabeth E., Xu, Ying, Cyster, Jason G.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776777/
https://www.ncbi.nlm.nih.gov/pubmed/19503106
http://dx.doi.org/10.1038/ni.1745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776777/
https://www.ncbi.nlm.nih.gov/pubmed/19503106
http://dx.doi.org/10.1038/ni.1745

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