Identifying Drug Effects via Pathway Alterations using an Integer Linear Programming Optimization Formulation on Phosphoproteomic Data

Understanding the mechanisms of cell function and drug action is a major endeavor in the pharmaceutical industry. Drug effects are governed by the intrinsic properties of the drug (i.e., selectivity and potency) and the specific signaling transduction network of the host (i.e., normal vs. diseased c...

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Detalles Bibliográficos
Autores principales: Mitsos, Alexander, Melas, Ioannis N., Siminelakis, Paraskeuas, Chairakaki, Aikaterini D., Saez-Rodriguez, Julio, Alexopoulos, Leonidas G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776985/
https://www.ncbi.nlm.nih.gov/pubmed/19997482
http://dx.doi.org/10.1371/journal.pcbi.1000591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776985/
https://www.ncbi.nlm.nih.gov/pubmed/19997482
http://dx.doi.org/10.1371/journal.pcbi.1000591

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