Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report

BACKGROUND: The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic sig...

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Autores principales: Al Achkar, Walid, Wafa, Abdulsamad, Mkrtchyan, Hasmik, Moassass, Faten, Liehr, Thomas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777175/
https://www.ncbi.nlm.nih.gov/pubmed/19900270
http://dx.doi.org/10.1186/1755-8166-2-21
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author Al Achkar, Walid
Wafa, Abdulsamad
Mkrtchyan, Hasmik
Moassass, Faten
Liehr, Thomas
author_facet Al Achkar, Walid
Wafa, Abdulsamad
Mkrtchyan, Hasmik
Moassass, Faten
Liehr, Thomas
author_sort Al Achkar, Walid
collection PubMed
description BACKGROUND: The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. RESULTS: Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. CONCLUSION: The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment.
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spelling pubmed-27771752009-11-15 Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report Al Achkar, Walid Wafa, Abdulsamad Mkrtchyan, Hasmik Moassass, Faten Liehr, Thomas Mol Cytogenet Case Report BACKGROUND: The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. RESULTS: Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. CONCLUSION: The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. BioMed Central 2009-11-09 /pmc/articles/PMC2777175/ /pubmed/19900270 http://dx.doi.org/10.1186/1755-8166-2-21 Text en Copyright © 2009 Al Achkar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Al Achkar, Walid
Wafa, Abdulsamad
Mkrtchyan, Hasmik
Moassass, Faten
Liehr, Thomas
Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
title Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
title_full Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
title_fullStr Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
title_full_unstemmed Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
title_short Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
title_sort novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with philadelphia chromosome: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777175/
https://www.ncbi.nlm.nih.gov/pubmed/19900270
http://dx.doi.org/10.1186/1755-8166-2-21
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AT wafaabdulsamad novelcomplextranslocationinvolving5differentchromosomesinachronicmyeloidleukemiawithphiladelphiachromosomeacasereport
AT mkrtchyanhasmik novelcomplextranslocationinvolving5differentchromosomesinachronicmyeloidleukemiawithphiladelphiachromosomeacasereport
AT moassassfaten novelcomplextranslocationinvolving5differentchromosomesinachronicmyeloidleukemiawithphiladelphiachromosomeacasereport
AT liehrthomas novelcomplextranslocationinvolving5differentchromosomesinachronicmyeloidleukemiawithphiladelphiachromosomeacasereport

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