Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions

Quinacrine is a potent antiprion compound in cell culture models of prion disease but has failed to show efficacy in animal bioassays and human clinical trials. Previous studies demonstrated that quinacrine inefficiently penetrates the blood-brain barrier (BBB), which could contribute to its lack of...

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Detalles Bibliográficos
Autores principales: Ghaemmaghami, Sina, Ahn, Misol, Lessard, Pierre, Giles, Kurt, Legname, Giuseppe, DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777304/
https://www.ncbi.nlm.nih.gov/pubmed/19956709
http://dx.doi.org/10.1371/journal.ppat.1000673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777304/
https://www.ncbi.nlm.nih.gov/pubmed/19956709
http://dx.doi.org/10.1371/journal.ppat.1000673

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