Predicting Protein Ligand Binding Sites by Combining Evolutionary Sequence Conservation and 3D Structure

Identifying a protein's functional sites is an important step towards characterizing its molecular function. Numerous structure- and sequence-based methods have been developed for this problem. Here we introduce ConCavity, a small molecule binding site prediction algorithm that integrates evolu...

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Detalles Bibliográficos
Autores principales: Capra, John A., Laskowski, Roman A., Thornton, Janet M., Singh, Mona, Funkhouser, Thomas A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777313/
https://www.ncbi.nlm.nih.gov/pubmed/19997483
http://dx.doi.org/10.1371/journal.pcbi.1000585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777313/
https://www.ncbi.nlm.nih.gov/pubmed/19997483
http://dx.doi.org/10.1371/journal.pcbi.1000585

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