Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells

Double strand breaks (DSB) are severe DNA lesions, and if not properly repaired, may lead to cell death or cancer. While there is considerable data on the repair of simple DSB (sDSB) by non-homologous end-joining (NHEJ), little is known about the repair of complex DSBs (cDSB), namely breaks with a n...

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Detalles Bibliográficos
Autores principales: Covo, Shay, de Villartay, Jean-Pierre, Jeggo, Penny A., Livneh, Zvi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777433/
https://www.ncbi.nlm.nih.gov/pubmed/19762482
http://dx.doi.org/10.1093/nar/gkp703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777433/
https://www.ncbi.nlm.nih.gov/pubmed/19762482
http://dx.doi.org/10.1093/nar/gkp703

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