Characterization of RNA aptamers that disrupt the RUNX1–CBFβ/DNA complex

The transcription factor RUNX1 (AML1) is an important regulator of haematopoiesis, and an important fusion partner in leukaemic translocations. High-affinity DNA binding by RUNX1 requires the interaction of the RUNX1 Runt-Homology-Domain (RHD) with the core-binding factor β protein (CBFβ). To genera...

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Detalles Bibliográficos
Autores principales: Barton, Jenny L., Bunka, David H. J., Knowling, Stuart E., Lefevre, Pascal, Warren, Alan J., Bonifer, Constanze, Stockley, Peter G.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777437/
https://www.ncbi.nlm.nih.gov/pubmed/19740763
http://dx.doi.org/10.1093/nar/gkp728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777437/
https://www.ncbi.nlm.nih.gov/pubmed/19740763
http://dx.doi.org/10.1093/nar/gkp728

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