The Obesity Susceptibility Gene Carboxypeptidase E Links FoxO1 Signaling in Hypothalamic Pro–opiomelanocortin Neurons with Regulation of Food Intake

Reduced food intake brings about an adaptive decrease in energy expenditure that contributes to the recidivism of obesity following weight loss. Insulin and leptin inhibit food intake through actions in the central nervous system that are partly mediated by FoxO1. We show that FoxO1 ablation in pro–...

Descripción completa

Detalles Bibliográficos
Autores principales: Plum, Leona, Lin, Hua V., Dutia, Roxanne, Tanaka, Jun, Aizawa, Kumiko S., Matsumoto, Michihiro, Kim, Andrea J., Cawley, Niamh X., Paik, Ji–Hye, Loh, Y. Peng, DePinho, Ronald A., Wardlaw, Sharon L., Accili, Domenico
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777744/
https://www.ncbi.nlm.nih.gov/pubmed/19767734
http://dx.doi.org/10.1038/nm.2026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777744/
https://www.ncbi.nlm.nih.gov/pubmed/19767734
http://dx.doi.org/10.1038/nm.2026

Ejemplares similares