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A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of ubiquitin-binding proteins Rad23 and Dsk2

BACKGROUND: Ubiquitin regulates a myriad of important cellular processes through covalent attachment to its substrates. A classic role for ubiquitin is to flag proteins for destruction by the proteasome. Recent studies indicate that ubiquitin-binding proteins (e.g. Rad23, Dsk2, Rpn10) play a pivotal...

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Detalles Bibliográficos
Autores principales: Liu, Chang, van Dyk, Dewald, Li, Yue, Andrews, Brenda, Rao, Hai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777868/
https://www.ncbi.nlm.nih.gov/pubmed/19909498
http://dx.doi.org/10.1186/1741-7007-7-75