Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes

The oncogene EVI1 has been implicated in the etiology of AML and MDS. Although AML cells are characterized by accelerated proliferation and differentiation arrest, MDS cells hyperproliferate when immature but fail to differentiate later and die instead. In agreement with its roles in AML and in imma...

Descripción completa

Detalles Bibliográficos
Autores principales: Konrad, Torsten A., Karger, Anna, Hackl, Hubert, Schwarzinger, Ilse, Herbacek, Irene, Wieser, Rotraud
Formato: Texto
Lenguaje:English
Publicado: The Society for Leukocyte Biology 2009
Materias:
Cell Development, Differentiation, & Trafficking
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777892/
https://www.ncbi.nlm.nih.gov/pubmed/19605700
http://dx.doi.org/10.1189/jlb.0109042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777892/
https://www.ncbi.nlm.nih.gov/pubmed/19605700
http://dx.doi.org/10.1189/jlb.0109042

Ejemplares similares