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Differential Base Stacking Interactions Induced by Trimethylene Interstrand DNA Cross-Links in the 5′-CpG-3′ and 5′-GpC-3′ Sequence Contexts

[Image: see text] Synthetically derived trimethylene interstrand DNA cross-links have been used as surrogates for the native cross-links that arise from the 1,N(2)-deoxyguanosine adducts derived from α,β-unsaturated aldehydes. The native enal-mediated cross-linking occurs in the 5′-CpG-3′ sequence c...

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Detalles Bibliográficos
Autores principales: Huang, Hai, Dooley, Patricia A., Harris, Constance M., Harris, Thomas M., Stone, Michael P.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778138/
https://www.ncbi.nlm.nih.gov/pubmed/19916525
http://dx.doi.org/10.1021/tx900225c