Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes

Objective. The purpose of this study was to establish the outlook for fetuses diagnosed with complete atrioventricular septal defect (cAVSD) prenatally and its relation to additional cardiac, extracardiac, and chromosomal abnormalities. Methods. We retrospectively reviewed fetal echocardiograms diag...

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Autores principales: Yıldırım, Gokhan, Gungorduk, Kemal, Yazıcıoğlu, Fehmi, Gul, Ahmet, Çakar, Fatma, Çelikkol, Özgü, Ceylan, Yavuz
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778174/
https://www.ncbi.nlm.nih.gov/pubmed/19960047
http://dx.doi.org/10.1155/2009/958496
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author Yıldırım, Gokhan
Gungorduk, Kemal
Yazıcıoğlu, Fehmi
Gul, Ahmet
Çakar, Fatma
Çelikkol, Özgü
Ceylan, Yavuz
author_facet Yıldırım, Gokhan
Gungorduk, Kemal
Yazıcıoğlu, Fehmi
Gul, Ahmet
Çakar, Fatma
Çelikkol, Özgü
Ceylan, Yavuz
author_sort Yıldırım, Gokhan
collection PubMed
description Objective. The purpose of this study was to establish the outlook for fetuses diagnosed with complete atrioventricular septal defect (cAVSD) prenatally and its relation to additional cardiac, extracardiac, and chromosomal abnormalities. Methods. We retrospectively reviewed fetal echocardiograms diagnosed with cAVSD from January 2002 to December 2007, comparing fetuses with and without aneuploidy. Results. Complete antrioventricular septal defect was confirmed in 62 fetuses. Mean maternal age was 28.79 ± 4.78 years (range 20–38). Mean gestational age was 23.69 ± 5.48 weeks (range 12–38). Fetal karyotype was known in all fetuses. An abnormal karyotype was found in 21 fetuses. Complete AVSD occurred without any other intracardiac abnormality in 28 fetuses. Extracardiac anomalies were present in 38 fetuses. As for pregnancy outcomes, there were 36 (58%) terminations of pregnancy and 4 (6.4%) intrauterine fetal deaths. In these four fetuses, complex cAVSD was associated with atrioventricular block (one case), heterotaxy (one case), and fetal hydrops (two cases). Of the 22 live births, 5 were neonatal deaths without surgery while 17 babies underwent surgery and 13 have survived to date. The mean survival age was 53 ± 4 months (range 22–64 m). Conclusion. AVSD is associated with chromosomal, other cardiac, and extracardiac abnormalities. The detection of these abnormalities is important in order to give the best indication of the likely outcome when counselling parents.
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spelling pubmed-27781742009-12-03 Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes Yıldırım, Gokhan Gungorduk, Kemal Yazıcıoğlu, Fehmi Gul, Ahmet Çakar, Fatma Çelikkol, Özgü Ceylan, Yavuz Obstet Gynecol Int Research Article Objective. The purpose of this study was to establish the outlook for fetuses diagnosed with complete atrioventricular septal defect (cAVSD) prenatally and its relation to additional cardiac, extracardiac, and chromosomal abnormalities. Methods. We retrospectively reviewed fetal echocardiograms diagnosed with cAVSD from January 2002 to December 2007, comparing fetuses with and without aneuploidy. Results. Complete antrioventricular septal defect was confirmed in 62 fetuses. Mean maternal age was 28.79 ± 4.78 years (range 20–38). Mean gestational age was 23.69 ± 5.48 weeks (range 12–38). Fetal karyotype was known in all fetuses. An abnormal karyotype was found in 21 fetuses. Complete AVSD occurred without any other intracardiac abnormality in 28 fetuses. Extracardiac anomalies were present in 38 fetuses. As for pregnancy outcomes, there were 36 (58%) terminations of pregnancy and 4 (6.4%) intrauterine fetal deaths. In these four fetuses, complex cAVSD was associated with atrioventricular block (one case), heterotaxy (one case), and fetal hydrops (two cases). Of the 22 live births, 5 were neonatal deaths without surgery while 17 babies underwent surgery and 13 have survived to date. The mean survival age was 53 ± 4 months (range 22–64 m). Conclusion. AVSD is associated with chromosomal, other cardiac, and extracardiac abnormalities. The detection of these abnormalities is important in order to give the best indication of the likely outcome when counselling parents. Hindawi Publishing Corporation 2009 2009-06-04 /pmc/articles/PMC2778174/ /pubmed/19960047 http://dx.doi.org/10.1155/2009/958496 Text en Copyright © 2009 Gokhan Yıldırım et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yıldırım, Gokhan
Gungorduk, Kemal
Yazıcıoğlu, Fehmi
Gul, Ahmet
Çakar, Fatma
Çelikkol, Özgü
Ceylan, Yavuz
Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes
title Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes
title_full Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes
title_fullStr Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes
title_full_unstemmed Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes
title_short Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes
title_sort prenatal diagnosis of complete atrioventricular septal defect: perinatal and neonatal outcomes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778174/
https://www.ncbi.nlm.nih.gov/pubmed/19960047
http://dx.doi.org/10.1155/2009/958496
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