Interactions between programmed death-1 and programmed death ligand-1 promote tolerance by blocking the T cell receptor-induced stop signal

Programmed death-1 (PD-1) is an inhibitory molecule expressed on activated T cells, however, the biological context in which PD-1 controls T cell tolerance remains unclear. Using two-photon laser-scanning microscopy, we showed that unlike naïve or activated islet antigen-specific T cells, tolerized...

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Detalles Bibliográficos
Autores principales: Fife, Brian T., Pauken, Kristen E., Eagar, Todd N., Obu, Takashi, Wu, Jenny, Tang, Qizhi, Azuma, Miyuki, Krummel, Matthew F., Bluestone, Jeffrey A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778301/
https://www.ncbi.nlm.nih.gov/pubmed/19783989
http://dx.doi.org/10.1038/ni.1790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778301/
https://www.ncbi.nlm.nih.gov/pubmed/19783989
http://dx.doi.org/10.1038/ni.1790

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