AIRE activated tissue specific genes have histone modifications associated with inactive chromatin

The Autoimmune Regulator (AIRE) protein is expressed in thymic medullary epithelial cells, where it promotes the ectopic expression of tissue-restricted antigens needed for efficient negative selection of developing thymocytes. Mutations in AIRE cause APECED syndrome, which is characterized by a bre...

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Detalles Bibliográficos
Autores principales: Org, Tõnis, Rebane, Ana, Kisand, Kai, Laan, Martti, Haljasorg, Uku, Andreson, Reidar, Peterson, Pärt
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778368/
https://www.ncbi.nlm.nih.gov/pubmed/19744957
http://dx.doi.org/10.1093/hmg/ddp433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778368/
https://www.ncbi.nlm.nih.gov/pubmed/19744957
http://dx.doi.org/10.1093/hmg/ddp433

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