Functional Role of P-Glycoprotein and Binding Protein Effect on the Placental Transfer of Lopinavir/Ritonavir in the Ex Vivo Human Perfusion Model

Aims. To study the influence of P-glycoprotein (P-glycoprotein, ABCB1, MDR1) function on placental transfer of lopinavir with ritonavir at different albumin concentrations. Methods. Cotyledons were perfused with lopinavir, ritonavir, and the internal control antipyrin, at various albumin concentrati...

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Detalles Bibliográficos
Autores principales: Ceccaldi, Pierre-Francois, Gavard, Laurent, Mandelbrot, Laurent, Rey, Elisabeth, Farinotti, Robert, Treluyer, Jean-Marc, Gil, Sophie
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778444/
https://www.ncbi.nlm.nih.gov/pubmed/19960055
http://dx.doi.org/10.1155/2009/726593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778444/
https://www.ncbi.nlm.nih.gov/pubmed/19960055
http://dx.doi.org/10.1155/2009/726593

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