Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels

BACKGROUND: TRPM8 is a non-selective cation channel that belongs to the melastatin subfamily of the transient receptor potential (TRP) ion channels. TRPM8 is activated by voltage, cold and cooling compounds such as menthol. Despite its essential role for cold temperature sensing in mammals, the phar...

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Detalles Bibliográficos
Autores principales: Malkia, Annika, Pertusa, María, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Viana, Félix
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778643/
https://www.ncbi.nlm.nih.gov/pubmed/19886999
http://dx.doi.org/10.1186/1744-8069-5-62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778643/
https://www.ncbi.nlm.nih.gov/pubmed/19886999
http://dx.doi.org/10.1186/1744-8069-5-62

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