Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by expansion of an unstable CAG repeat in the coding sequence of the Huntingtin (HTT) gene. Instability affects both germline and somatic cells. Somatic instability increases with age and is tissue-specific. In particu...

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Detalles Bibliográficos
Autores principales: Goula, Agathi-Vassiliki, Berquist, Brian R., Wilson, David M., Wheeler, Vanessa C., Trottier, Yvon, Merienne, Karine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778875/
https://www.ncbi.nlm.nih.gov/pubmed/19997493
http://dx.doi.org/10.1371/journal.pgen.1000749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778875/
https://www.ncbi.nlm.nih.gov/pubmed/19997493
http://dx.doi.org/10.1371/journal.pgen.1000749

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