A Novel Enediynyl Peptide Inhibitor of Furin That Blocks Processing of proPDGF-A, B and proVEGF-C

BACKGROUND: Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis. As a result it is considered a major target for i...

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Detalles Bibliográficos
Autores principales: Basak, Ajoy, Khatib, Abdel-Majid, Mohottalage, Dayani, Basak, Sarmistha, Kolajova, Maria, Bag, Subhendu Sekhar, Basak, Amit
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778948/
https://www.ncbi.nlm.nih.gov/pubmed/19956642
http://dx.doi.org/10.1371/journal.pone.0007700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778948/
https://www.ncbi.nlm.nih.gov/pubmed/19956642
http://dx.doi.org/10.1371/journal.pone.0007700

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