Domain Requirements and Sequence Specificity of DNA Binding for the Forkhead Transcription Factor FOXP3

The forkhead, winged-helix transcription factor FOXP3 is preferentially expressed in T regulatory (Treg) cells and is critical for their immunosuppressive function. Mutations that abolish FOXP3 function lead to systemic autoimmunity in mice and humans. However, the manner by which FOXP3 recognizes c...

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Detalles Bibliográficos
Autores principales: Koh, Kian Peng, Sundrud, Mark S., Rao, Anjana
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779587/
https://www.ncbi.nlm.nih.gov/pubmed/19956618
http://dx.doi.org/10.1371/journal.pone.0008109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779587/
https://www.ncbi.nlm.nih.gov/pubmed/19956618
http://dx.doi.org/10.1371/journal.pone.0008109

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