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Domain Requirements and Sequence Specificity of DNA Binding for the Forkhead Transcription Factor FOXP3
The forkhead, winged-helix transcription factor FOXP3 is preferentially expressed in T regulatory (Treg) cells and is critical for their immunosuppressive function. Mutations that abolish FOXP3 function lead to systemic autoimmunity in mice and humans. However, the manner by which FOXP3 recognizes c...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779587/ https://www.ncbi.nlm.nih.gov/pubmed/19956618 http://dx.doi.org/10.1371/journal.pone.0008109 |