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Loss of PDZK1 Causes Coronary Artery Occlusion and Myocardial Infarction in Paigen Diet-Fed Apolipoprotein E Deficient Mice

BACKGROUND: PDZK1 is a four PDZ-domain containing protein that binds to the carboxy terminus of the HDL receptor, scavenger receptor class B type I (SR-BI), and regulates its expression, localization and function in a tissue-specific manner. PDZK1 knockout (KO) mice are characterized by a marked red...

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Detalles Bibliográficos
Autores principales: Yesilaltay, Ayce, Daniels, Kathleen, Pal, Rinku, Krieger, Monty, Kocher, Olivier
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779610/
https://www.ncbi.nlm.nih.gov/pubmed/19956623
http://dx.doi.org/10.1371/journal.pone.0008103