Aging-related chromatin defects via loss of the NURD complex

Physiological and premature aging are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD remodeling complex as a key modulator of these aging-associated chromatin defects. We demonstrate loss of several NURD components during...

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Detalles Bibliográficos
Autores principales: Pegoraro, Gianluca, Kubben, Nard, Wickert, Ute, Göhler, Heike, Hoffmann, Katrin, Misteli, Tom
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779731/
https://www.ncbi.nlm.nih.gov/pubmed/19734887
http://dx.doi.org/10.1038/ncb1971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779731/
https://www.ncbi.nlm.nih.gov/pubmed/19734887
http://dx.doi.org/10.1038/ncb1971

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