Aging-related chromatin defects via loss of the NURD complex

Physiological and premature aging are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD remodeling complex as a key modulator of these aging-associated chromatin defects. We demonstrate loss of several NURD components during...

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Detalles Bibliográficos
Autores principales: Pegoraro, Gianluca, Kubben, Nard, Wickert, Ute, Göhler, Heike, Hoffmann, Katrin, Misteli, Tom
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779731/
https://www.ncbi.nlm.nih.gov/pubmed/19734887
http://dx.doi.org/10.1038/ncb1971
Descripción
Sumario:Physiological and premature aging are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD remodeling complex as a key modulator of these aging-associated chromatin defects. We demonstrate loss of several NURD components during premature and normal aging and we find aging-associated reduction of HDAC1 activity. Silencing of individual NURD subunits recapitulates some chromatin defects associated with aging and we provide evidence that structural chromatin defects precede DNA damage accumulation. These results outline a molecular mechanism for chromatin defects during aging.

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