Aging-related chromatin defects via loss of the NURD complex

Physiological and premature aging are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD remodeling complex as a key modulator of these aging-associated chromatin defects. We demonstrate loss of several NURD components during...

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Autores principales: Pegoraro, Gianluca, Kubben, Nard, Wickert, Ute, Göhler, Heike, Hoffmann, Katrin, Misteli, Tom
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779731/
https://www.ncbi.nlm.nih.gov/pubmed/19734887
http://dx.doi.org/10.1038/ncb1971
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author Pegoraro, Gianluca
Kubben, Nard
Wickert, Ute
Göhler, Heike
Hoffmann, Katrin
Misteli, Tom
author_facet Pegoraro, Gianluca
Kubben, Nard
Wickert, Ute
Göhler, Heike
Hoffmann, Katrin
Misteli, Tom
author_sort Pegoraro, Gianluca
collection PubMed
description Physiological and premature aging are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD remodeling complex as a key modulator of these aging-associated chromatin defects. We demonstrate loss of several NURD components during premature and normal aging and we find aging-associated reduction of HDAC1 activity. Silencing of individual NURD subunits recapitulates some chromatin defects associated with aging and we provide evidence that structural chromatin defects precede DNA damage accumulation. These results outline a molecular mechanism for chromatin defects during aging.
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spelling pubmed-27797312010-04-01 Aging-related chromatin defects via loss of the NURD complex Pegoraro, Gianluca Kubben, Nard Wickert, Ute Göhler, Heike Hoffmann, Katrin Misteli, Tom Nat Cell Biol Article Physiological and premature aging are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD remodeling complex as a key modulator of these aging-associated chromatin defects. We demonstrate loss of several NURD components during premature and normal aging and we find aging-associated reduction of HDAC1 activity. Silencing of individual NURD subunits recapitulates some chromatin defects associated with aging and we provide evidence that structural chromatin defects precede DNA damage accumulation. These results outline a molecular mechanism for chromatin defects during aging. 2009-09-06 2009-10 /pmc/articles/PMC2779731/ /pubmed/19734887 http://dx.doi.org/10.1038/ncb1971 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Pegoraro, Gianluca
Kubben, Nard
Wickert, Ute
Göhler, Heike
Hoffmann, Katrin
Misteli, Tom
Aging-related chromatin defects via loss of the NURD complex
title Aging-related chromatin defects via loss of the NURD complex
title_full Aging-related chromatin defects via loss of the NURD complex
title_fullStr Aging-related chromatin defects via loss of the NURD complex
title_full_unstemmed Aging-related chromatin defects via loss of the NURD complex
title_short Aging-related chromatin defects via loss of the NURD complex
title_sort aging-related chromatin defects via loss of the nurd complex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779731/
https://www.ncbi.nlm.nih.gov/pubmed/19734887
http://dx.doi.org/10.1038/ncb1971
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