Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway

BACKGROUND: p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function and exertion of dominant-negative effects over the remaining wild-type protein, several p53 mutants can gain novel oncogenic functions (gain-of-function, GOF) th...

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Detalles Bibliográficos
Autores principales: Dong, Peixin, Xu, Zhujie, Jia, Nan, Li, Dajin, Feng, Youji
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779797/
https://www.ncbi.nlm.nih.gov/pubmed/19917135
http://dx.doi.org/10.1186/1476-4598-8-103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779797/
https://www.ncbi.nlm.nih.gov/pubmed/19917135
http://dx.doi.org/10.1186/1476-4598-8-103

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