NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

BACKGROUND: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development. In all crystal structures of the proteases to date, the NS2B cofactor is located far from the substrate binding site (open conformation)...

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Detalles Bibliográficos
Autores principales: Su, Xun-Cheng, Ozawa, Kiyoshi, Qi, Ruhu, Vasudevan, Subhash G., Lim, Siew P., Otting, Gottfried
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780355/
https://www.ncbi.nlm.nih.gov/pubmed/19997625
http://dx.doi.org/10.1371/journal.pntd.0000561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780355/
https://www.ncbi.nlm.nih.gov/pubmed/19997625
http://dx.doi.org/10.1371/journal.pntd.0000561

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