Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

BACKGROUND: The mitotic Aurora-A kinase exerts crucial functions in maintaining mitotic fidelity. As a bona fide oncoprotein, Aurora-A aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by which Aurora-A enhances cancer cell survival remain to be elucidated. RESULTS: Here...

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Detalles Bibliográficos
Autores principales: Yao, Jin-e, Yan, Min, Guan, Zhong, Pan, Chao-bin, Xia, Liang-ping, Li, Chuan-xing, Wang, Li-hui, Long, Zi-jie, Zhao, Yan, Li, Ming-wei, Zheng, Fei-meng, Xu, Jie, Lin, Dong-jun, Liu, Quentin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780390/
https://www.ncbi.nlm.nih.gov/pubmed/19891769
http://dx.doi.org/10.1186/1476-4598-8-95

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780390/
https://www.ncbi.nlm.nih.gov/pubmed/19891769
http://dx.doi.org/10.1186/1476-4598-8-95

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