Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitro

BACKGROUND: Imatinib mesylate has significantly improved survival and quality of life of patients with gastrointestinal stromal tumors (GISTs). However, the molecular mechanism through which imatinib exerts its anti-tumor effects is not clear. Previously, we found up-regulation of insulin-like growt...

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Detalles Bibliográficos
Autores principales: Dupart, Jheri J, Trent, Jonathan C, Lee, Ho-Young, Hess, Kenneth R, Godwin, Andrew K, Taguchi, Takahiro, Zhang, Wei
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780392/
https://www.ncbi.nlm.nih.gov/pubmed/19903356
http://dx.doi.org/10.1186/1476-4598-8-99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780392/
https://www.ncbi.nlm.nih.gov/pubmed/19903356
http://dx.doi.org/10.1186/1476-4598-8-99

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