Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens

OBJECTIVE: To study how tolerance to GAD65 affects the development of autoimmunity to other β-cell autoantigens (β-CAAs) in GAD65-transgenic (GAD-tg) NOD mice. RESEARCH DESIGN AND METHODS: We used ELISPOT to characterize the frequency and functional phenotype of T-cell responses to GAD65 and other β...

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Detalles Bibliográficos
Autores principales: Tian, Jide, Dang, Hoa, von Boehmer, Harald, Jaeckel, Elmar, Kaufman, Daniel L.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780885/
https://www.ncbi.nlm.nih.gov/pubmed/19741165
http://dx.doi.org/10.2337/db08-0851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780885/
https://www.ncbi.nlm.nih.gov/pubmed/19741165
http://dx.doi.org/10.2337/db08-0851

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