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Reverse genetics through random mutagenesis in Histoplasma capsulatum

BACKGROUND: The dimorphic fungal pathogen Histoplasma capsulatum causes respiratory and systemic disease in humans and other mammals. Progress in understanding the mechanisms underlying the biology and the pathogenesis of Histoplasma has been hindered by a shortage of methodologies for mutating a ge...

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Detalles Bibliográficos
Autores principales: Youseff, Brian H, Dougherty, Julie A, Rappleye, Chad A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781022/
https://www.ncbi.nlm.nih.gov/pubmed/19919692
http://dx.doi.org/10.1186/1471-2180-9-236