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Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism
The aim of the present study was to test the hypothesis that elevation of prorenin in plasma is sufficient to induce cardiac fibrosis. Normotensive cyp1a1ren-2 transgenic rats with normal plasma prorenin and aldosterone levels were given 0.125% indole-3-carbinol (I3C) orally for a period of 12 wk. P...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Physiological Society
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781377/ https://www.ncbi.nlm.nih.gov/pubmed/19749160 http://dx.doi.org/10.1152/ajpheart.01135.2008 |