Hepatocyte Nuclear Factor 1α Plays a Critical Role in PCSK9 Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

PCSK9 is a natural inhibitor of LDL receptor (LDLR) that binds the extracellular domain of LDLR and triggers its intracellular degradation. PCSK9 and LDLR are coordinately regulated at the transcriptional level by sterols through their promoter-imbedded sterol response elements (SRE) and co-induced...

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Detalles Bibliográficos
Autores principales: Li, Hai, Dong, Bin, Park, Sahng Wook, Lee, Hyun-Sook, Chen, Wei, Liu, Jingwen
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781434/
https://www.ncbi.nlm.nih.gov/pubmed/19687008
http://dx.doi.org/10.1074/jbc.M109.052407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781434/
https://www.ncbi.nlm.nih.gov/pubmed/19687008
http://dx.doi.org/10.1074/jbc.M109.052407

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