Cargando…

Hepatocyte Nuclear Factor 1α Plays a Critical Role in PCSK9 Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

PCSK9 is a natural inhibitor of LDL receptor (LDLR) that binds the extracellular domain of LDLR and triggers its intracellular degradation. PCSK9 and LDLR are coordinately regulated at the transcriptional level by sterols through their promoter-imbedded sterol response elements (SRE) and co-induced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hai, Dong, Bin, Park, Sahng Wook, Lee, Hyun-Sook, Chen, Wei, Liu, Jingwen
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781434/ https://www.ncbi.nlm.nih.gov/pubmed/19687008 http://dx.doi.org/10.1074/jbc.M109.052407

Ejemplares similares

Temporal and Spatial Regulation of the Phosphatidate Phosphatases Lipin 1 and 2
por: Grimsey, Neil, et al.
Publicado: (2008)

Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella pneumophila
por: Brombacher, Eva, et al.
Publicado: (2009)

Identification of a Cardiolipin-specific Phospholipase Encoded by the Gene CLD1 (YGR110W) in Yeast
por: Beranek, Andreas, et al.
Publicado: (2009)

PapA3 Is an Acyltransferase Required for Polyacyltrehalose Biosynthesis in Mycobacterium tuberculosis
por: Hatzios, Stavroula K., et al.
Publicado: (2009)

Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function
por: Yin, Wu, et al.
Publicado: (2009)

Phosphatidylethanolamine-esterified Eicosanoids in the Mouse: TISSUE LOCALIZATION AND INFLAMMATION-DEPENDENT FORMATION IN Th-2 DISEASE
por: Morgan, Alwena H., et al.
Publicado: (2009)

Structural Basis of the Catalytic Mechanism Operating in Open-Closed Conformers of Lipocalin Type Prostaglandin D Synthase
por: Kumasaka, Takashi, et al.
Publicado: (2009)

Wolbachia Lipoprotein Stimulates Innate and Adaptive Immunity through Toll-like Receptors 2 and 6 to Induce Disease Manifestations of Filariasis
por: Turner, Joseph D., et al.
Publicado: (2009)

5-Lipoxygenase-mediated Endogenous DNA Damage
por: Jian, Wenying, et al.
Publicado: (2009)

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation
por: Kosenko, Tanja, et al.
Publicado: (2013)

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles
por: Sarkar, Samantha K., et al.
Publicado: (2020)

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation
por: Pajed, Laura, et al.
Publicado: (2019)

Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice
por: Pouwer, Marianne G, et al.
Publicado: (2019)

High-density lipoprotein cholesterol as a predictor of clinical outcomes in patients achieving low-density lipoprotein cholesterol targets with statins after percutaneous coronary intervention
por: Seo, Suk Min, et al.
Publicado: (2011)

ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding
por: Lund Winther, Anne-Marie, et al.
Publicado: (2021)

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites
por: Botté, Cyrille Y., et al.
Publicado: (2011)

Purification, Identification, and Cloning of Lysoplasmalogenase, the Enzyme That Catalyzes Hydrolysis of the Vinyl Ether Bond of Lysoplasmalogen
por: Wu, Lai-Chu, et al.
Publicado: (2011)

Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrations(1)(2)(3)(4)
por: Li, Zhaoping, et al.
Publicado: (2010)

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
por: He, Shaoqing, et al.
Publicado: (2010)

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid
por: Isobe, Yosuke, et al.
Publicado: (2012)

Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women(1)(2)(3)
por: Lacroix, Émilie, et al.
Publicado: (2012)

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
por: Huang, Yongcheng, et al.
Publicado: (2011)

Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme
por: Lamour, Nadia F., et al.
Publicado: (2011)

Functional and Topological Analysis of Yeast Acyl-CoA:Diacylglycerol Acyltransferase 2, an Endoplasmic Reticulum Enzyme Essential for Triacylglycerol Biosynthesis
por: Liu, Qin, et al.
Publicado: (2011)

Lipid Raft Association and Cholesterol Sensitivity of P2X1-4 Receptors for ATP: CHIMERAS AND POINT MUTANTS IDENTIFY INTRACELLULAR AMINO-TERMINAL RESIDUES INVOLVED IN LIPID REGULATION OF P2X1 RECEPTORS
por: Allsopp, Rebecca C., et al.
Publicado: (2010)

Ataxin-1 Poly(Q)-induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid-derived Neuroprotectin D1
por: Calandria, Jorgelina M., et al.
Publicado: (2012)

Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation
por: Thomas, Christopher P., et al.
Publicado: (2010)

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response
por: Ariyama, Hiroyuki, et al.
Publicado: (2010)

Metabolic and Transcriptional Responses of Glycerolipid Pathways to a Perturbation of Glycerol 3-Phosphate Metabolism in Arabidopsis
por: Shen, Wenyun, et al.
Publicado: (2010)

Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages
por: Aflaki, Elma, et al.
Publicado: (2011)

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
por: Chandak, Prakash G., et al.
Publicado: (2010)

Kdo(2)-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy
por: Sims, Kacee, et al.
Publicado: (2010)

Identification of a Mammalian-type Phosphatidylglycerophosphate Phosphatase in the Eubacterium Rhodopirellula baltica
por: Teh, Phildrich G., et al.
Publicado: (2013)

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase
por: Rengachari, Srinivasan, et al.
Publicado: (2013)

Rapid Production of Platelet-activating Factor Is Induced by Protein Kinase Cα-mediated Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 Protein
por: Morimoto, Ryo, et al.
Publicado: (2014)

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
por: Saeed, Ahmed A., et al.
Publicado: (2014)

High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F(2α) concentrations relative to a control high–oleic acid meal: a randomized controlled trial(1)(2)(3)(4)
por: Purcell, Robert, et al.
Publicado: (2014)

Biosynthesis and Translocation of Unsulfated Acyltrehaloses in Mycobacterium tuberculosis
por: Belardinelli, Juan Manuel, et al.
Publicado: (2014)

Vitellogenin Receptor Mutation Leads to the Oogenesis Mutant Phenotype “scanty vitellin” of the Silkworm, Bombyx mori
por: Lin, Ying, et al.
Publicado: (2013)

Mechanisms Responsible for the Compositional Heterogeneity of Nascent High Density Lipoprotein
por: Lund-Katz, Sissel, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_phs6du266hchif4rhtji5mij37