Cargando…

Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities

BACKGROUND: PEA-15 is a phosphoprotein that binds and regulates ERK MAP kinase and RSK2 and is highly expressed throughout the brain. PEA-15 alters c-Fos and CREB-mediated transcription as a result of these interactions. To determine if PEA-15 contributes to the function of the nervous system we tes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramos, Joe W, Townsend, David A, Piarulli, Dawn, Kolata, Stefan, Light, Kenneth, Hale, Gregory, Matzel, Louis D
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781817/ https://www.ncbi.nlm.nih.gov/pubmed/19917132 http://dx.doi.org/10.1186/1471-2202-10-134

Ejemplares similares

A Dopaminergic Gene Cluster in the Prefrontal Cortex Predicts Performance Indicative of General Intelligence in Genetically Heterogeneous Mice
por: Kolata, Stefan, et al.
Publicado: (2010)

Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
por: Verschoor, Pola J., et al.
Publicado: (2021)

PEA‐15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia
por: Greig, Fiona H., et al.
Publicado: (2017)

PEA15 loss of function and defective cerebral development in the domestic cat
por: Graff, Emily C., et al.
Publicado: (2020)

PEA-15 potentiates H-Ras mediated epithelial cell transformation through Phospholipase D
por: Sulzmaier, Florian J., et al.
Publicado: (2011)

Dopamine D1 receptor density in the mPFC responds to cognitive demands and receptor turnover contributes to general cognitive ability in mice
por: Wass, Christopher, et al.
Publicado: (2018)

Clozapine Impairs Insulin Action by Up-Regulating Akt Phosphorylation and Ped/Pea-15 Protein Abundance
por: Panariello, Fabio, et al.
Publicado: (2012)

On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities
por: Wei, Yufeng
Publicado: (2015)

Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates α5β1 integrin endocytosis
por: Caliva, Maisel J., et al.
Publicado: (2021)

A Non-Invasive Approach in the Assessment of Stress Phenomena and Impairment Values in Pea Seeds Caused by Pea Weevil
por: Keszthelyi, Sándor, et al.
Publicado: (2021)

Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training
por: Wass, Christopher, et al.
Publicado: (2013)

Human-like problem-solving abilities in large language models using ChatGPT
por: Orrù, Graziella, et al.
Publicado: (2023)

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination
por: Jones, Brian W, et al.
Publicado: (2016)

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice
por: Perruolo, Giuseppe, et al.
Publicado: (2016)

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK
por: Mace, Peter D., et al.
Publicado: (2013)

Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory
por: Kreis, Anna, et al.
Publicado: (2023)

Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia
por: SUNG, Jin-Hee, et al.
Publicado: (2017)

Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin
por: Dilruba, Shahana, et al.
Publicado: (2020)

Vitamin D(3) signalling in the brain enhances the function of phosphoprotein enriched in astrocytes – 15 kD (PEA-15)
por: Obradovic, Darja, et al.
Publicado: (2009)

Peas and Primroses
por: Wilcox, Lynne S.
Publicado: (2005)

Pea in the Trachea
Publicado: (1907)

Domestication of Pea (Pisum sativum L.): The Case of the Abyssinian Pea
por: Weeden, Norman F.
Publicado: (2018)

The causes of variation in learning and behavior: why individual differences matter
por: Sauce, Bruno, et al.
Publicado: (2013)

A multi-faceted role of dual-state dopamine signaling in working memory, attentional control, and intelligence
por: Matzel, Louis D., et al.
Publicado: (2023)

Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure
por: Lu, Cai-Ling, et al.
Publicado: (2014)

Thrombin-induced microglial activation impairs hippocampal neurogenesis and spatial memory ability in mice
por: Yang, Yuan, et al.
Publicado: (2015)

Audiospatial cognitive ability of visually impaired athletes in static and dynamic spatial cognitive tasks
por: Shiota, Kotomi, et al.
Publicado: (2017)

CD146 Deletion in the Nervous System Impairs Appetite, Locomotor Activity and Spatial Learning in Mice
por: Tu, Tao, et al.
Publicado: (2013)

Phosphoprotein enriched in astrocytes (PEA)-15: A potential therapeutic target in multiple disease states
por: Greig, Fiona H., et al.
Publicado: (2014)

Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells
por: Hindupur, Sravanth K, et al.
Publicado: (2014)

PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway
por: Tang, Bo, et al.
Publicado: (2019)

The microRNA212 regulated PEA15 promotes ovarian cancer progression by inhibiting of apoptosis
por: Luo, Yonghong, et al.
Publicado: (2020)

Pea Breeding for Intercropping With Cereals: Variation for Competitive Ability and Associated Traits, and Assessment of Phenotypic and Genomic Selection Strategies
por: Annicchiarico, Paolo, et al.
Publicado: (2021)

Peas Out of the Pod
por: Kirtsios, Theocharis N., et al.
Publicado: (2021)

Histamine H(1) receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
por: Cheng, Li, et al.
Publicado: (2021)

Response of Pea Varieties to Damage Degree of Pea Weevil, Bruchus pisorum L.
por: Nikolova, Ivelina Mitkova
Publicado: (2016)

Spatial Abilities for Architecture: Cross Sectional and Longitudinal Assessment With Novel and Existing Spatial Ability Tests
por: Berkowitz, Michal, et al.
Publicado: (2021)

The pea and the sun : a mathematical paradox /
por: Wapner, Leonard M., 1948-
Publicado: (2005)

PED/PEA-15 Controls Fibroblast Motility and Wound Closure by ERK1/2-Dependent Mechanisms
por: Buonomo, Roberta, et al.
Publicado: (2012)

PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation
por: Iovino, S, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_l4tcr1tfg44mj5odd989ei601s