A tumor suppressive activity of Drosophila Polycomb genes mediated by JAK/STAT signaling

A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points to an oncogenic role for PcG in human cancer 1,2. Here we demonstrate using Drosophila that a conventional PcG complex can also have a potent...

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Detalles Bibliográficos
Autores principales: Classen, Anne-Kathrin, Bunker, Brandon D., Harvey, Kieran F., Vaccari, Thomas, Bilder, David
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782793/
https://www.ncbi.nlm.nih.gov/pubmed/19749759
http://dx.doi.org/10.1038/ng.445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782793/
https://www.ncbi.nlm.nih.gov/pubmed/19749759
http://dx.doi.org/10.1038/ng.445

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