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A tumor suppressive activity of Drosophila Polycomb genes mediated by JAK/STAT signaling
A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points to an oncogenic role for PcG in human cancer 1,2. Here we demonstrate using Drosophila that a conventional PcG complex can also have a potent...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782793/ https://www.ncbi.nlm.nih.gov/pubmed/19749759 http://dx.doi.org/10.1038/ng.445 |