Inhibitor Hijacking of Akt Activation

The kinase Akt plays a central role as a regulator of multiple growth factor input signals, making it an attractive anti-cancer drug target. A-443654 is an ATP-competitive Akt inhibitor. Unexpectedly, treatment of cells with A-443654 causes paradoxical hyperphosphorylation of Akt at its two regulato...

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Detalles Bibliográficos
Autores principales: Okuzumi, Tatsuya, Fiedler, Dorothea, Zhang, Chao, Gray, Daniel C., Aizenstein, Brian, Hoffman, Randy, Shokat, Kevan M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783590/
https://www.ncbi.nlm.nih.gov/pubmed/19465931
http://dx.doi.org/10.1038/nchembio.183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783590/
https://www.ncbi.nlm.nih.gov/pubmed/19465931
http://dx.doi.org/10.1038/nchembio.183

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