Extracellular histones are major mediators of death in sepsis

Hyper–inflammatory responses can lead to a variety of diseases including sepsis1. We now report that extracellular histones released in response to inflammatory challenge contribute to endothelial dysfunction, organ failure and death during sepsis. They can be targeted pharmacologically by antibody...

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Detalles Bibliográficos
Autores principales: Xu, Jun, Zhang, Xiaomei, Pelayo, Rosana, Monestier, Marc, Ammollo, Concetta T., Semeraro, Fabrizio, Taylor, Fletcher B., Esmon, Naomi, Lupu, Florea, Esmon, Charles T.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783754/
https://www.ncbi.nlm.nih.gov/pubmed/19855397
http://dx.doi.org/10.1038/nm.2053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783754/
https://www.ncbi.nlm.nih.gov/pubmed/19855397
http://dx.doi.org/10.1038/nm.2053

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