Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries

The cytochrome P450 (CYP) gene family strongly influences drug development. We determined potency values for 17,143 compounds against recombinant CYP 1A2, 2C9, 2C19, 2D6, and 3A4 enzymes through an in vitro bioluminescent assay. The compound collections included substances from typical libraries and...

Descripción completa

Detalles Bibliográficos
Autores principales: Veith, Henrike, Southall, Noel, Huang, Ruili, James, Tim, Fayne, Darren, Artemenko, Natalia, Shen, Min, Inglese, James, Austin, Christopher P., Lloyd, David G., Auld, Douglas S.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783980/
https://www.ncbi.nlm.nih.gov/pubmed/19855396
http://dx.doi.org/10.1038/nbt.1581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783980/
https://www.ncbi.nlm.nih.gov/pubmed/19855396
http://dx.doi.org/10.1038/nbt.1581

Ejemplares similares