Predicting new molecular targets for known drugs

Whereas drugs are intended to be selective, at least some bind to several physiologic targets, explaining both side effects and efficacy. As many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here, we compared 3,665 FDA-approved and investigatio...

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Detalles Bibliográficos
Autores principales: Keiser, Michael J., Setola, Vincent, Irwin, John J., Laggner, Christian, Abbas, Atheir, Hufeisen, Sandra J., Jensen, Niels H., Kuijer, Michael B., Matos, Roberto C., Tran, Thuy B., Whaley, Ryan, Glennon, Richard A., Hert, Jérôme, Thomas, Kelan L.H., Edwards, Douglas D., Shoichet, Brian K., Roth, Bryan L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784146/
https://www.ncbi.nlm.nih.gov/pubmed/19881490
http://dx.doi.org/10.1038/nature08506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784146/
https://www.ncbi.nlm.nih.gov/pubmed/19881490
http://dx.doi.org/10.1038/nature08506

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