Cargando…

Predicting new molecular targets for known drugs

Whereas drugs are intended to be selective, at least some bind to several physiologic targets, explaining both side effects and efficacy. As many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here, we compared 3,665 FDA-approved and investigatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keiser, Michael J., Setola, Vincent, Irwin, John J., Laggner, Christian, Abbas, Atheir, Hufeisen, Sandra J., Jensen, Niels H., Kuijer, Michael B., Matos, Roberto C., Tran, Thuy B., Whaley, Ryan, Glennon, Richard A., Hert, Jérôme, Thomas, Kelan L.H., Edwards, Douglas D., Shoichet, Brian K., Roth, Bryan L.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784146/ https://www.ncbi.nlm.nih.gov/pubmed/19881490 http://dx.doi.org/10.1038/nature08506

Ejemplares similares

Quantifying Biogenic Bias in Screening Libraries
por: Hert, Jérôme, et al.
Publicado: (2009)

Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen
por: Laggner, Christian, et al.
Publicado: (2011)

The Chemical Basis of Pharmacology
por: Keiser, Michael J., et al.
Publicado: (2010)

In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding
por: Lemieux, George A., et al.
Publicado: (2013)

Ligand Discovery from a Dopamine D(3) Receptor Homology Model and Crystal Structure
por: Carlsson, Jens, et al.
Publicado: (2011)

Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method
por: Abbas, Atheir I., et al.
Publicado: (2010)

Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes
por: Choi, Jihoon, et al.
Publicado: (2018)

Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors
por: Ferreira, Rafaela S., et al.
Publicado: (2010)

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
por: Mysinger, Michael M., et al.
Publicado: (2012)

Speech Outcomes after Tonsillectomy in Patients with Known Velopharyngeal Insufficiency
por: Paulson, L. M., et al.
Publicado: (2012)

Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo
por: Allen, J A, et al.
Publicado: (2011)

Type I interferon regulates cytokine‐delayed neutrophil apoptosis, reactive oxygen species production and chemokine expression
por: Glennon‐Alty, L., et al.
Publicado: (2020)

Ligand Pose and Orientational Sampling in Molecular Docking
por: Coleman, Ryan G., et al.
Publicado: (2013)

The Botryosphaeriaceae: genera and species known from culture
por: Phillips, A.J.L., et al.
Publicado: (2013)

Restless Legs Syndrome: Known Knowns and Known Unknowns
por: Antelmi, Elena, et al.
Publicado: (2022)

Properties of the lightest known caesium isotopes, $^{114-118}$Cs
por: D'Auria, J M, et al.
Publicado: (1978)

Renal denervation in the antihypertensive arsenal – knowns and known unknowns
por: Messerli, Franz H., et al.
Publicado: (2023)

And They Said It Couldn’t Be Done: Predicting Known Driver Mutations From H&E Slides
por: Montalto, Michael C., et al.
Publicado: (2019)

Mitochondrial Inheritance in Phytopathogenic Fungi—Everything Is Known, or Is It?
por: Mendoza, Hector, et al.
Publicado: (2020)

The known knowns, known unknowns, and unknown unknowns of surveys and sleep
por: Shaker, Marcus, et al.
Publicado: (2022)

Predicted Biological Activity of Purchasable Chemical Space
por: Irwin, John J., et al.
Publicado: (2017)

Question what is “known”
por: Heller, H. Craig
Publicado: (2021)

Japanese Encephalitis Virus in Australia: From Known Known to Known Unknown
por: van den Hurk, Andrew F., et al.
Publicado: (2019)

Engineered Accumulation of Bicarbonate in Plant Chloroplasts: Known Knowns and Known Unknowns
por: Rottet, Sarah, et al.
Publicado: (2021)

Song exposure regulates known and novel microRNAs in the zebra finch auditory forebrain
por: Gunaratne, Preethi H, et al.
Publicado: (2011)

The known roots of a known problem
por: Rosenblatt, Eduardo
Publicado: (2018)

Whiplash in individuals with known pre–accident, clinical neck status
por: Sjaastad, O., et al.
Publicado: (2006)

Sepsis-related stress response: known knowns, known unknowns, and unknown unknowns
por: Peng, Jinmin, et al.
Publicado: (2010)

Vitamin D deficiency and supplementation in critical illness—the known knowns and known unknowns
por: Nair, Priya, et al.
Publicado: (2018)

Automated Docking Screens: A Feasibility Study
por: Irwin, John J., et al.
Publicado: (2009)

Known allosteric proteins have central roles in genetic disease
por: Abrusán, György, et al.
Publicado: (2022)

Successful Surgical Removal of the Largest Known Spleen
por: Hall, David J., et al.
Publicado: (2020)

Valvular Lesions of the Heart, Commonly Known as Cardiac Murmurs
por: Campbell, J. L.
Publicado: (1899)

Diplomacia constitucional
por: Glennon, Michael J., 1947-
Publicado: (1996)

Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders
por: Oud, M S, et al.
Publicado: (2021)

Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition
por: Baeyens, A, et al.
Publicado: (2002)

Arterial Hæmorrhage. Was It Known to the Ancients?
por: Moore, W. J.
Publicado: (1876)

Effect of the COVID-19 Pandemic on Cancer Clinician Decision Making: Known Knowns and Known Unknowns
por: Boon, I.S., et al.
Publicado: (2020)

Oxidative Stress in Cytokine-Induced Dysfunction of the Pancreatic Beta Cell: Known Knowns and Known Unknowns
por: Kowluru, Anjaneyulu
Publicado: (2020)

Known unknowns: building an ethics of uncertainty into genomic medicine
por: Newson, Ainsley J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2rn5m3674n9d5arrnt4cgcaop6