Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

BACKGROUND: Regulatory T cells (Tregs) can employ a cell contact- and granzyme B-dependent mechanism to mediate suppression of bystander T and B cells. Murine studies indicate that granzyme B is involved in the Treg-mediated suppression of anti-tumor immunity in the tumor microenvironment and in the...

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Detalles Bibliográficos
Autores principales: Efimova, Olga V, Kelley, Todd W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784757/
https://www.ncbi.nlm.nih.gov/pubmed/19930596
http://dx.doi.org/10.1186/1471-2172-10-59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784757/
https://www.ncbi.nlm.nih.gov/pubmed/19930596
http://dx.doi.org/10.1186/1471-2172-10-59

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