Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

The bifunctional trypanothione synthetase-amidase (TRYS) comprises two structurally distinct catalytic domains for synthesis and hydrolysis of trypanothione (N(1),N(8)-bis(glutathionyl)spermidine). This unique dithiol plays a pivotal role in thiol-redox homeostasis and in defence against chemical an...

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Detalles Bibliográficos
Autores principales: Wyllie, Susan, Oza, Sandra L, Patterson, Stephen, Spinks, Daniel, Thompson, Stephen, Fairlamb, Alan H
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784880/
https://www.ncbi.nlm.nih.gov/pubmed/19558432
http://dx.doi.org/10.1111/j.1365-2958.2009.06761.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784880/
https://www.ncbi.nlm.nih.gov/pubmed/19558432
http://dx.doi.org/10.1111/j.1365-2958.2009.06761.x

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