Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity

BACKGROUND: A hallmark of the prion diseases is the conversion of the host-encoded cellular prion protein (PrP(C)) into a disease related, alternatively folded isoform (PrP(Sc)). The accumulation of PrP(Sc) within the brain is associated with synapse loss and ultimately neuronal death. Novel therape...

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Detalles Bibliográficos
Autores principales: Bate, Clive, Tayebi, Mourad, Diomede, Luisa, Salmona, Mario, Williams, Alun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784943/
https://www.ncbi.nlm.nih.gov/pubmed/20011040
http://dx.doi.org/10.1371/journal.pone.0008221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784943/
https://www.ncbi.nlm.nih.gov/pubmed/20011040
http://dx.doi.org/10.1371/journal.pone.0008221

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