Apolipoprotein E4 Domain Interaction Induces Endoplasmic Reticulum Stress and Impairs Astrocyte Function

Domain interaction, a structural property of apolipoprotein E4 (apoE4), is predicted to contribute to the association of apoE4 with Alzheimer disease. Arg-61 apoE mice, a gene-targeted mouse model specific for domain interaction, have lower brain apoE levels and synaptic, functional, and cognitive d...

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Detalles Bibliográficos
Autores principales: Zhong, Ning, Ramaswamy, Gayathri, Weisgraber, Karl H.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785655/
https://www.ncbi.nlm.nih.gov/pubmed/19666463
http://dx.doi.org/10.1074/jbc.M109.014464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785655/
https://www.ncbi.nlm.nih.gov/pubmed/19666463
http://dx.doi.org/10.1074/jbc.M109.014464

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