Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase

Cyclic ADP-ribose (cADPR) is a universal calcium messenger molecule that regulates many physiological processes. The production and degradation of cADPR are catalyzed by a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california (ADPRAC) and CD38 from human. Although ADPR...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Qun, Graeff, Richard, Kriksunov, Irina A., Jiang, Hong, Zhang, Bo, Oppenheimer, Norman, Lin, Hening, Potter, Barry V. L., Lee, Hon Cheung, Hao, Quan
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785692/
https://www.ncbi.nlm.nih.gov/pubmed/19640846
http://dx.doi.org/10.1074/jbc.M109.031005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785692/
https://www.ncbi.nlm.nih.gov/pubmed/19640846
http://dx.doi.org/10.1074/jbc.M109.031005

Ejemplares similares