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Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase

Cyclic ADP-ribose (cADPR) is a universal calcium messenger molecule that regulates many physiological processes. The production and degradation of cADPR are catalyzed by a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california (ADPRAC) and CD38 from human. Although ADPR...

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Detalles Bibliográficos
Autores principales:	Liu, Qun, Graeff, Richard, Kriksunov, Irina A., Jiang, Hong, Zhang, Bo, Oppenheimer, Norman, Lin, Hening, Potter, Barry V. L., Lee, Hon Cheung, Hao, Quan
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785692/ https://www.ncbi.nlm.nih.gov/pubmed/19640846 http://dx.doi.org/10.1074/jbc.M109.031005

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