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Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse

Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attention as a potential risk locus for autism-spectrum disorders, a...

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Detalles Bibliográficos
Autores principales: Veenstra-VanderWeele, Jeremy, Jessen, Tammy N., Thompson, Brent J., Carter, Michelle, Prasad, Harish C., Steiner, Jennifer A., Sutcliffe, James. S., Blakely, Randy D.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786076/
https://www.ncbi.nlm.nih.gov/pubmed/19960097
http://dx.doi.org/10.1007/s11689-009-9020-0